Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after the 2015–16 terrorist attacks
Identifieur interne : 000823 ( Main/Exploration ); précédent : 000822; suivant : 000824Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after the 2015–16 terrorist attacks
Auteurs : A. Brunet [Canada] ; A. Ayrolles [France] ; L. Gambotti [France] ; R. Maatoug [France] ; C. Estellat [France] ; M. Descamps [France] ; N. Girault [France] ; K. Kalalou ; G. Abgrall [France] ; F. Ducrocq [France] ; G. Vaiva [France] ; N. Jaafari [France] ; M. Krebs [France] ; E. Castaigne [France] ; I. Hanafy ; M. Benoit [France] ; S. Mouchabac [France] ; M. Cabie [France] ; O. Guillin [France] ; F. Hodeib [France] ; I. Durand-Zaleski [France] ; B. Millet [France]Source :
- BMC Psychiatry [ 1471-244X ] ; 2019-12.
Descripteurs français
- Wicri :
- topic : Terrorisme.
English descriptors
Abstract
BACKGROUND:The Paris and Nice terrorist attacks affected a thousand of trauma victims and first-line responders. Because there were concerns that this might represent the first of several attacks, there was a need to quickly enhance the local capacities to treat a large number of individuals suffering from trauma-related disorders. Since Reconsolidation Therapy (RT) is brief, relatively easy to learn, well tolerated and effective, it appeared as the ideal first-line treatment to teach to clinicians in this context.METHODS:This study protocol is a two-arm non-randomized, multicenter controlled trial, comparing RT to treatment as usual for the treatment of trauma-related disorders. RT consists of actively recalling one's traumatic event under the influence of the ß-blocker propranolol, once a week, for 10-25 min with a therapist, over 6 consecutive weeks. This protocol evaluates the feasibility, effectiveness, and cost-utility of implementing RT as part of a large multi-center (N = 400) pragmatic trial with a one-year follow-up.DISCUSSION:Paris MEM is the largest trial to date assessing the efficiency of RT in the aftermath of a large-scale man-made disaster. RT could possibly reinforce the therapeutic arsenal for the treatment of patients suffering from trauma-related disorders, not only for communities in western countries but also worldwide for terror- or disaster-stricken communities.
Url:
DOI: 10.1186/s12888-019-2283-4
Affiliations:
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Le document en format XML
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Durand-Zaleski</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-245941" status="OLD"> <idno type="IdRef">181496658</idno> <idno type="RNSR">201420728Z</idno> <orgName>Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables</orgName> <orgName type="acronym">ECEVE (U1123 / UMR_S_1123)</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>48 Boulevard Sérurier 75019 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR_S_1123" active="#struct-300301" type="direct"></relation> <relation name="U1123" active="#struct-303623" type="direct"></relation> <relation active="#struct-426105" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_S_1123" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="U1123" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-426105" type="direct"><org type="institution" xml:id="struct-426105" status="VALID"> <orgName>AP-HP Hôpital universitaire Robert-Debré [Paris]</orgName> <desc> <address> <addrLine> 48, boulevard Sérurier – 75019 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://robertdebre.aphp.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Millet, B" sort="Millet, B" uniqKey="Millet B" first="B." last="Millet">B. Millet</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-02378997</idno><idno type="halId">hal-02378997</idno><idno type="halUri">https://hal.sorbonne-universite.fr/hal-02378997</idno><idno type="url">https://hal.sorbonne-universite.fr/hal-02378997</idno><idno type="doi">10.1186/s12888-019-2283-4</idno><date when="2019-12">2019-12</date><idno type="wicri:Area/Hal/Corpus">000100</idno><idno type="wicri:Area/Hal/Curation">000100</idno><idno type="wicri:Area/Hal/Checkpoint">000012</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000012</idno><idno type="wicri:doubleKey">1471-244X:2019:Brunet A:paris:mem:a</idno><idno type="wicri:Area/Main/Merge">000824</idno><idno type="wicri:Area/Main/Curation">000823</idno><idno type="wicri:Area/Main/Exploration">000823</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after the 2015–16 terrorist attacks</title><author><name sortKey="Brunet, A" sort="Brunet, A" uniqKey="Brunet A" first="A." last="Brunet">A. Brunet</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-134741" status="VALID"> <orgName>McGill University</orgName> <desc> <address> <addrLine>845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.mcgill.ca/</ref> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Ayrolles, A" sort="Ayrolles, A" uniqKey="Ayrolles A" first="A." last="Ayrolles">A. Ayrolles</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Gambotti, L" sort="Gambotti, L" uniqKey="Gambotti L" first="L." last="Gambotti">L. Gambotti</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Maatoug, R" sort="Maatoug, R" uniqKey="Maatoug R" first="R." last="Maatoug">R. Maatoug</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Estellat, C" sort="Estellat, C" uniqKey="Estellat C" first="C." last="Estellat">C. Estellat</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Descamps, M" sort="Descamps, M" uniqKey="Descamps M" first="M." last="Descamps">M. Descamps</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Girault, N" sort="Girault, N" uniqKey="Girault N" first="N." last="Girault">N. Girault</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Kalalou, K" sort="Kalalou, K" uniqKey="Kalalou K" first="K." last="Kalalou">K. Kalalou</name></author><author><name sortKey="Abgrall, G" sort="Abgrall, G" uniqKey="Abgrall G" first="G." last="Abgrall">G. Abgrall</name><affiliation wicri:level="1"><hal:affiliation type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Ducrocq, F" sort="Ducrocq, F" uniqKey="Ducrocq F" first="F." last="Ducrocq">F. Ducrocq</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-425779" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Lille]</orgName> <orgName type="acronym">CHRU Lille</orgName> <desc> <address> <addrLine>2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chru-lille.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Vaiva, G" sort="Vaiva, G" uniqKey="Vaiva G" first="G." last="Vaiva">G. Vaiva</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-425779" status="VALID"> <orgName>Centre Hospitalier Régional Universitaire [Lille]</orgName> <orgName type="acronym">CHRU Lille</orgName> <desc> <address> <addrLine>2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chru-lille.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Jaafari, N" sort="Jaafari, N" uniqKey="Jaafari N" first="N." last="Jaafari">N. Jaafari</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182192" status="VALID"> <idno type="IdRef">168201887</idno> <orgName>Laboratoire de neurosciences expérimentales et cliniques</orgName> <orgName type="acronym">LNEC</orgName> <desc> <address> <addrLine>Bâtiment B36 Pôle Biologie-santé, 1 rue Georges Bonnet BP 633 TSA 51106 86073 POITIERS cedex9</addrLine> <country key="FR"></country> </address> <ref type="url">http://lnec.labo.univ-poitiers.fr/</ref> </desc> <listRelation> <relation name="U1084" active="#struct-54493" type="direct"></relation> <relation name="U1084" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle name="U1084" active="#struct-54493" type="direct"><org type="institution" xml:id="struct-54493" status="VALID"> <orgName>Université de Poitiers</orgName> <desc> <address> <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-poitiers.fr/</ref> </desc> </org></tutelle><tutelle name="U1084" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Poitiers</settlement><region type="old region" nuts="2">Poitou-Charentes</region><region type="region" nuts="2">Nouvelle-Aquitaine</region></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Krebs, M" sort="Krebs, M" uniqKey="Krebs M" first="M." last="Krebs">M. Krebs</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-470444" status="VALID"> <orgName>Centre Hospitalier Sainte Anne [Paris]</orgName> <desc> <address> <addrLine>1 Rue Cabanis, 75014 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ch-sainte-anne.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Castaigne, E" sort="Castaigne, E" uniqKey="Castaigne E" first="E." last="Castaigne">E. Castaigne</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-312432" status="VALID"> <orgName>AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)</orgName> <desc> <address> <addrLine>78 Rue du Général Leclerc 94270 Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Hanafy, I" sort="Hanafy, I" uniqKey="Hanafy I" first="I." last="Hanafy">I. Hanafy</name></author><author><name sortKey="Benoit, M" sort="Benoit, M" uniqKey="Benoit M" first="M." last="Benoit">M. Benoit</name><affiliation wicri:level="1"><hal:affiliation type="regroupinstitution" xml:id="struct-523042" status="VALID"> <orgName>Université Côte d'Azur </orgName> <orgName type="acronym">UCA</orgName> <date type="start">2015-03-01</date> <desc> <address> <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mouchabac, S" sort="Mouchabac, S" uniqKey="Mouchabac S" first="S." last="Mouchabac">S. Mouchabac</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-116979" status="VALID"> <orgName>Service de psychiatrie adulte [CHU Saint-Antoine]</orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75012 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-454982" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID"> <orgName>CHU Saint-Antoine [APHP]</orgName> <desc> <address> <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cabie, M" sort="Cabie, M" uniqKey="Cabie M" first="M." last="Cabie">M. Cabie</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-355262" status="VALID"> <orgName>Hôpitaux de Saint Maurice</orgName> <orgName type="acronym">HNSM</orgName> <desc> <address> <addrLine>12 - 14 rue du Val d’Osne - 94410 Saint-Maurice</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Guillin, O" sort="Guillin, O" uniqKey="Guillin O" first="O." last="Guillin">O. Guillin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182184" status="OLD"> <idno type="RNSR">201220161S</idno> <idno type="IdRef">198011067</idno> <orgName>Génétique du cancer et des maladies neuropsychiatriques</orgName> <orgName type="acronym">GMFC</orgName> <date type="end">2016-12-31</date> <desc> <address> <addrLine>22 Boulevard Gambetta 76183 Rouen Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300318" type="direct"></relation> <relation active="#struct-455934" type="indirect"></relation> <relation name="U1079" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"> <idno type="ISNI">0000000121083034</idno> <idno type="IdRef">026403919</idno> <orgName>Université de Rouen Normandie</orgName> <orgName type="acronym">UNIROUEN</orgName> <date type="start">1966-01-01</date> <desc> <address> <addrLine>1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rouen.fr/</ref> </desc> <listRelation> <relation active="#struct-455934" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-455934" type="indirect"><org type="regroupinstitution" xml:id="struct-455934" status="VALID"> <idno type="IdRef">190906332</idno> <idno type="ISNI">0000000417859671 </idno> <orgName>Normandie Université</orgName> <orgName type="acronym">NU</orgName> <date type="start">2015-01-01</date> <desc> <address> <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.normandie-univ.fr/</ref> </desc> </org></tutelle><tutelle name="U1079" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Hodeib, F" sort="Hodeib, F" uniqKey="Hodeib F" first="F." last="Hodeib">F. Hodeib</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Durand Zaleski, I" sort="Durand Zaleski, I" uniqKey="Durand Zaleski I" first="I." last="Durand-Zaleski">I. Durand-Zaleski</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-245941" status="OLD"> <idno type="IdRef">181496658</idno> <idno type="RNSR">201420728Z</idno> <orgName>Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables</orgName> <orgName type="acronym">ECEVE (U1123 / UMR_S_1123)</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>48 Boulevard Sérurier 75019 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UMR_S_1123" active="#struct-300301" type="direct"></relation> <relation name="U1123" active="#struct-303623" type="direct"></relation> <relation active="#struct-426105" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_S_1123" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle name="U1123" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-426105" type="direct"><org type="institution" xml:id="struct-426105" status="VALID"> <orgName>AP-HP Hôpital universitaire Robert-Debré [Paris]</orgName> <desc> <address> <addrLine> 48, boulevard Sérurier – 75019 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://robertdebre.aphp.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Millet, B" sort="Millet, B" uniqKey="Millet B" first="B." last="Millet">B. Millet</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-456706" status="VALID"> <orgName>Service de Psychiatrie adulte [CHU Pitié-Salpêtrière]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1186/s12888-019-2283-4</idno><series><title level="j">BMC Psychiatry</title><idno type="ISSN">1471-244X</idno><imprint><date type="datePub">2019-12</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Cost-effectiveness trial</term><term>Post-traumatic stress disorder (PTSD)</term><term>Reconsolidation</term><term>Terrorism</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Terrorisme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND:The Paris and Nice terrorist attacks affected a thousand of trauma victims and first-line responders. Because there were concerns that this might represent the first of several attacks, there was a need to quickly enhance the local capacities to treat a large number of individuals suffering from trauma-related disorders. Since Reconsolidation Therapy (RT) is brief, relatively easy to learn, well tolerated and effective, it appeared as the ideal first-line treatment to teach to clinicians in this context.METHODS:This study protocol is a two-arm non-randomized, multicenter controlled trial, comparing RT to treatment as usual for the treatment of trauma-related disorders. RT consists of actively recalling one's traumatic event under the influence of the ß-blocker propranolol, once a week, for 10-25 min with a therapist, over 6 consecutive weeks. This protocol evaluates the feasibility, effectiveness, and cost-utility of implementing RT as part of a large multi-center (N = 400) pragmatic trial with a one-year follow-up.DISCUSSION:Paris MEM is the largest trial to date assessing the efficiency of RT in the aftermath of a large-scale man-made disaster. RT could possibly reinforce the therapeutic arsenal for the treatment of patients suffering from trauma-related disorders, not only for communities in western countries but also worldwide for terror- or disaster-stricken communities.</p> </div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Nouvelle-Aquitaine</li><li>Poitou-Charentes</li></region><settlement><li>Poitiers</li></settlement><orgName><li>Université de Poitiers</li></orgName></list><tree><noCountry><name sortKey="Hanafy, I" sort="Hanafy, I" uniqKey="Hanafy I" first="I." last="Hanafy">I. Hanafy</name><name sortKey="Kalalou, K" sort="Kalalou, K" uniqKey="Kalalou K" first="K." last="Kalalou">K. Kalalou</name></noCountry><country name="Canada"><noRegion><name sortKey="Brunet, A" sort="Brunet, A" uniqKey="Brunet A" first="A." last="Brunet">A. Brunet</name></noRegion></country><country name="France"><noRegion><name sortKey="Ayrolles, A" sort="Ayrolles, A" uniqKey="Ayrolles A" first="A." last="Ayrolles">A. Ayrolles</name></noRegion><name sortKey="Abgrall, G" sort="Abgrall, G" uniqKey="Abgrall G" first="G." last="Abgrall">G. Abgrall</name><name sortKey="Benoit, M" sort="Benoit, M" uniqKey="Benoit M" first="M." last="Benoit">M. Benoit</name><name sortKey="Cabie, M" sort="Cabie, M" uniqKey="Cabie M" first="M." last="Cabie">M. Cabie</name><name sortKey="Castaigne, E" sort="Castaigne, E" uniqKey="Castaigne E" first="E." last="Castaigne">E. Castaigne</name><name sortKey="Descamps, M" sort="Descamps, M" uniqKey="Descamps M" first="M." last="Descamps">M. Descamps</name><name sortKey="Ducrocq, F" sort="Ducrocq, F" uniqKey="Ducrocq F" first="F." last="Ducrocq">F. Ducrocq</name><name sortKey="Durand Zaleski, I" sort="Durand Zaleski, I" uniqKey="Durand Zaleski I" first="I." last="Durand-Zaleski">I. Durand-Zaleski</name><name sortKey="Estellat, C" sort="Estellat, C" uniqKey="Estellat C" first="C." last="Estellat">C. Estellat</name><name sortKey="Gambotti, L" sort="Gambotti, L" uniqKey="Gambotti L" first="L." last="Gambotti">L. Gambotti</name><name sortKey="Girault, N" sort="Girault, N" uniqKey="Girault N" first="N." last="Girault">N. Girault</name><name sortKey="Guillin, O" sort="Guillin, O" uniqKey="Guillin O" first="O." last="Guillin">O. Guillin</name><name sortKey="Hodeib, F" sort="Hodeib, F" uniqKey="Hodeib F" first="F." last="Hodeib">F. Hodeib</name><name sortKey="Jaafari, N" sort="Jaafari, N" uniqKey="Jaafari N" first="N." last="Jaafari">N. Jaafari</name><name sortKey="Krebs, M" sort="Krebs, M" uniqKey="Krebs M" first="M." last="Krebs">M. Krebs</name><name sortKey="Maatoug, R" sort="Maatoug, R" uniqKey="Maatoug R" first="R." last="Maatoug">R. Maatoug</name><name sortKey="Millet, B" sort="Millet, B" uniqKey="Millet B" first="B." last="Millet">B. Millet</name><name sortKey="Mouchabac, S" sort="Mouchabac, S" uniqKey="Mouchabac S" first="S." last="Mouchabac">S. Mouchabac</name><name sortKey="Vaiva, G" sort="Vaiva, G" uniqKey="Vaiva G" first="G." last="Vaiva">G. Vaiva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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